Implantation Support

Blastocyst Culture, Assisted Hatching, Embryo Glue

Blastocyst Culture

In most infertility treatment clinics performing IVF treatment, embryos develop in the laboratory until they reach 6-8 cell stage on day 2 or 3. The highest quality embryos are transferred to the uterus, while the others are usually frozen. It is possible to allow embryos to culture to a later stage before transferring them into a woman’s body. Embryos at the blastocyst stage are transferred into the uterus on the fourth or fifth day after fertilisation. Development of embryos to the blastocyst stage greatly increases the chances of getting a positive treatment outcome.

Assisted Embryo Hatching (AH)

The assisted hatching procedure involves incision (making a small hole) in the area surrounding the embryo prior to transferring it to the uterus. The cells which form the early embryo are surrounded by a so-called transparent sheath (zona pellucida). Assisted Hatching can be performed by an embryologist using laser, mechanical or chemical, on the day of a 5 day embryo transfer, just before the transfer of the embryo to the recipient. This technique may improve the success rates of implantation, especially in women over the age of 37 or women with 2 or more unsuccessful IVF cycles / cycles with poor embryos quality.

Embryo Glue

EmbryoGlue is a hyaluronan-enriched embryo transfer (ET) medium which aids in implantation of embryos, hence, improves pregnancy rates in in-vitro fertilization-ET cycles (IVF-ET).


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